Andor-Zyla-5.5-CL3-2-min-1024x1024-min Andor-Zyla-5.5-CL3-4-min-1024x1024-min Andor-Zyla-5.5-CL3-3-min-1024x1024-min

Andor Zyla 5.5 sCMOS Monochrome Microscope Camera CL3

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Includes CL3 Card and Cables


  • Model: Zyla 5.5
  • Sensor type: Front Illuminated Scientific CMOS
  • Active pixels (W x H): 2560 x 2160 (5.5 Megapixel)
  • Sensor size: 16.6 x 14.0 mm, 21.8 mm diagonal
  • Pixel readout rate (MHz):
    • 200 (100 MHz x 2 sensor halves
    • 560 (280 MHz x 2 sensor halves)
  • Read noise (e-) Median [rms]:
    • Rolling Shutter:
      • @200 MHz: 0.9 [1.2]
      • @560 MHz: 1.2 [1.6]
    • Global Shutter: 
      • @200 MHz: 2.3 [2.5]
      • @560 MHz: 2.4 [2.6]
  • Maximum Quantum Efficiency: 60%
  • Sensor Operating Temperature:
    • Air cooled: 0ºC (up to 30ºC ambient)
    • Water cooled: -10ºC
  • Dark current, e-/pixel/sec @ min temp:
    • Air cooled: .10
    • Water cooled: .019
  • Readout modes: Rolling Shutter and True Global Shutter (Snapshot)
  • Maximum dynamic range: 33,000:1
  • Photon Response Non-Uniformity (PRNU):
    • Half-light range: < 0.01%
    • Low light range: <0.1%
  • Pre-defined Region of Interest (ROI): 2048 x 2048, 1920 x 1080, 1392 x 1040, 512 x 512, 128 x 128
  • User defined ROI (Granularity):Yes (1 pixel)
  • Data range: 12-bit (fastest USB 3.0 speeds) and 16-bit (maximum dynamic range)
  • Interface: Camera Link 10-tap

General Specifications:

  • Pixel size (W x H): 6.5 μm
  • Pixel well depth (e-): 30,000
  • Linearity (%, maximum):
    • Full light range: Better than 99.8%
    • Low light range (< 1000 electrons signal): Better than 99.9%
  • MTF (Nyquist @ 555 nm): 45%
  • Pixel binning: Hardware binning: 2 x 2, 3 x 3, 4 x 4, 8 x 8
  • Anti-blooming factor: x 10,000
  • I/O: External Trigger, Fire, Fire n, Fire All, Fire Any, Arm
  • Trigger Modes: Internal, External, External Start, External Exposure, Software Trigger
  • Software Exposure Events: Start exposure – End exposure (row 1), Start exposure – End exposure (row n)
  • Hardware timestamp accuracy: 25 ns
  • Internal memory: 1 GB

Andor’s Zyla 5.5 sCMOS camera offers high speed, high sensitivity imaging performance in a remarkably light and compact, TE cooled design. Zyla is ideally suited to many cutting-edge applications that push the boundaries of speed, offering sustained frame rate performance of up to 100 fps, faster with ROIs.

A highly cost-effective USB 3.0 version is available offering 40 fps and 0.9 e- rms read noise, representing an ideal low light ‘workhorse’ upgrade camera solution for both microscopy and physical science applications, in either research or OEM environments.

Rolling and Global (Snapshot) Shutter readout inherent to Zyla 5.5 ensures maximum application flexibility. Global shutter to the in particular provides an important ‘freeze frame’ exposure mechanism that emulates that of an interline CCD, overcoming the transient readout nature of Rolling shutter mode.

The Andor GPU Express library has been created to simplify and optimize data transfers from camera to a CUDA-enabled NVidia Graphical Processing Unit (GPU) card to facilitate accelerated GPU processing as part of the acquisition pipeline.


  • 0.9 e- read noise: Offers lower detection limit than any CCD.
  • Rolling and Global (Snapshot) shutter: Maximum exposure and readout flexibility across all applications. Snapshot for ‘interline CCD mode’ freeze frame capture of fast moving/changing events.
  • Sub-microsecond inter-frame gap: Global Shutter offers down to 100 ns inter-frame gap, ideal for PIV applications
  • Industry Fastest Frame Rates: 100 fps (full frame) sustained via Camera Link . Industry fastest USB 3.0 frame rates, 40 fps (full frame) – faster speeds with ROI.
  • 5.5 megapixel sensor format and 6.5 μm pixels: Delivers extremely sharp resolution over a 22 mm diagonal field of view; ideal for cell microscopy, astronomy and area scanning applications such as digital pathology and high content screening.
  • Dual-Gain Amplifiers: Maximum well depth and lowest noise in one frame, affording extended dynamic range of 25,000:1.
  • 12-bit and 16-bit modes: 12-bit for smaller file size and absolute fastest frame rates through USB 3.0; 16-bit for full dynamic range.
  • Low dark current: 0.10 e-/pix/s: Extremely competitive optimized darkcurrent. Maintains low noise advantage across range of exposure conditions.
  • TE cooling to 0° C in 35 °C ambient: Ideal for OEM integration into enclosed systems.
  • GPU Express: Simplify and optimize data transfers from camera to Graphical Processing Unit (GPU) card to facilitate accelerated GPU processing as part of the acquisition pipeline.
  • Compact and Light: Ideal for integration into space restrictive set-ups. Perfect for OEM.
  • Hardware Timestamp:  FPGA generated timestamp with 25ns accuracy.
  • Dynamic Baseline Clamp: Essential to ensure quantitative accuracy across the image area and between successive images of a kinetic series.
  • Spurious Noise Filter: Real time FPGA filter that identifies and compensates for spurious high noise pixels.
  • Single window design: Single input window with double AR coating ensures maximum photon throughput.
  • Comprehensive trigger modes and I/O: Communication and synchronization within intricate experimental set-ups.

Additional information

Equipment Condition


Frame Rate

100 fps

Camera Resolution

5 Megapixel


Zyla 5.5 CL3

Sensor Type


Color or Monochrome