The Eclipse E400 biological microscope is Nikon’s mid-level research instrument. Though designed for stability, the instrument features a compact design, which was intended to help maintain a suitable comfort level for the microscopist over extended periods of observation.

Nikon Eclipse E400 Biological Microscope
The rigid frame of the E400 helps reduce vibrations, a characteristic that is particularly advantageous during imaging for critical photomicrography applications. Head and eye position are also given special attention in the Eclipse design and among the newer features are a lower eyepiece tube angle, an optional eye-level riser, and an optional binocular head, which offers variable inclination angles. A low-profile stage incorporated into the instrument facilitates specimen manipulation and Nikon designers carefully positioned the stage handle and focus control knobs so that they could be operated with a single hand, freeing the other hand of the microscopist for additional manipulations.

The Eclipse E400 features a quintuple revolving nosepiece and Nikon’s CFI60 optical system.